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While GLP-1 drugs are generally well tolerated, they may not be suitable for everyone
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Additionally, NSAIDs can affect kidney function by reducing renal blood flow, particularly in patients with pre-existing kidney disease, dehydration, or those taking other medications that stress the kidneys
Peripheral vasculopathy and nephropathy in association with phentermine

What can I do to manage constipation while taking GLP-1 medications
