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This landmark study of over 17,000 adults with established cardiovascular disease and overweight or obesity without diabetes demonstrated a 20% reduction in major adverse cardiovascular events with semaglutide 2.4 mg compared to placebo

A systematic review found that hair loss associated with GLP-1 receptor agonist use is a documented phenomenon, primarily related to the telogen effluvium triggered by rapid weight loss and nutritional deficiency rather than a direct drug effect

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This means access is limited and tightly controlled

Switching typically requires 1-2 weeks transition time and medical guidance to ensure safe titration