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Eli Lilly has developed tirzepatide, which adds activity of another incretin-like peptide, GIP, to the GLP-1 backbone

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Elevated expression of ER stress markers, including GRP78, ATF-6, X-box binding protein-1, C/EBP homologous protein (CHOP), and phospho-Jun N-terminal kinase (p-JNK), was evident in the hippocampal CA1 of diabetic rats, 68 which may ultimately affect synaptic plasticity