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The instrument may tear the wall of the colon which may require surgery to repair

Lancet 398, 143155 (2021)

Remember that the ultimate goal is consistency

According to the MHRA-approved SmPC, semaglutide works by binding to GLP-1 receptors in multiple tissues, including the pancreas, where it enhances glucose-dependent insulin secretion, and in the brain, where it reduces appetite and food intake through effects on satiety centres

Cymbal, Michael et al