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Description
The functional relationships between the intestine and the pancreatic islet were named by Unger and Eisentraut in 1969 [30] as the enteroinsular axis, while the criteria formulated by Creutzfeldt [31] considered a molecule to be incretin when it is secreted in response to nutrients, and that physiological concentrations increased the secretion of insulin in the presence of high glucose concentrations

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