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doi: 10.4103/0019-5359.100341 251 KobayashiMAkakiJNinomiyaKYoshikawaMMuraokaOMorikawaT OdawaraMet al

The label was updated with clinical trials data that supporting its effectiveness and safety for the longer period of use

Nausea is a very common side effect that typically improves over time

All three doses of orforglipron (6 mg, 12 mg, and 36 mg) studied in that trial met the primary and all key secondary endpoints by showing significant weight loss, meaningful A1C reductions, and improvements in cardiometabolic risk factors compared with placebo at 72 weeks

These perspectives reflect personal comfort levels and preferences rather than established medical guidance