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On examination, he has a body mass index (calculated as weight in kilograms divided by height in meters squared) of 40, a blood pressure of 144/86 mm/Hg, and well-demarcated red, scaly plaques on the extensor surfaces of the arms, legs, trunk, and scalp, involving 25% of the body surface area
there were no unexpected safety concerns and the safety profile was consistent with other GLP-1RAs
After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis
