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The 50% and 90% effective concentrations (EC50 and EC90) were in the range of 0.0008 micromolar to greater than 35 micromolar and 0.004 micromolar to greater than 100 micromolar, respectively (1 micromolar=0.284 microgram per mL)

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Thus, it was a vicious cycle that greatly influenced how I managed my diabetes

It means that long-term weight maintenance often requires ongoing intervention, whether that is continued medication, established lifestyle changes, or both