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Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low)

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Farxiga (Dapagliflozin) is a medication used to treat type 2 diabetes and more

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Sibutramine (formerly sold under the brand name Meridia) was approved by the FDA in 1997 but was pulled from the U.S

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