tirzepatide nash Consistent improvements in liver histology across subgroups in a post hoc analysis of the SYNERGY-NASH trial with Consistent improvements in liver histology
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Mechanistically, GLP-1R signaling spans Gs-cAMP/PKA, -arrestin-dependent pathways, and additional routes (including Gq contexts), aligning with anti-inflammatory, natriuretic, and antifibrotic effects observed preclinically and clinically

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