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The study adds on additional data to what weve already previously known about GLP-1 containing agents: these drugs hope to reduce risk for cardiovascular complications from obesity, said Yu-Ming Ni, MD, a cardiologist and lipidologist at MemorialCare Heart and Vascular Institute at Orange Coast Medical Center in Fountain Valley, CA

Dose adjustments to those drugs are usually needed

Tirzepatide activates both the GLP-1 and GIP receptors from one 39-residue peptide, which is the main variable researchers compare in incretin studies

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But for people who cannot tolerate stronger GLP-1 agonists, liraglutide offers a gentler entry point with a well-established safety record spanning over a decade of real-world use