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For SGLT2is, the following effects were observed in the animal models: metabolic improvements (reduced body weight, improved glucose metabolism, and insulin sensitivity), hormonal effects (decreased testosterone, LH, FSH, and increased estradiol), reduced visceral fat accumulation, and ovarian effects (decreased cystic follicles, increased corpus luteum formation, and improved follicular development)

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10.3390/ijms20174092 [DOI] [PMC free article] [PubMed] [Google Scholar] McMahon, L

They are relatively simple chemical structures that are quite stable at room temperature

These results support the potential of this molecule for people living with type 2 diabetes. Retatrutide also showed clinically meaningful improvements from baseline across key cardiovascular risk factors, including non-HDL cholesterol, triglycerides and systolic blood pressure