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September 1, 2025

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The SURPASS-3 trial and its MRI substudy showed that, in adults with T2DM and BMI 25 kg/m 2 , 52 weeks of tirzepatide treatment significantly reduced VAT and abdominal subcutaneous adipose tissue (ASAT) across all dose groups, accompanied by reductions in liver fat and improvements in glycemic control, body weight, lipid parameters, and liver enzymes [98, 101]

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