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Blood pressure improvements were equally striking, with 41% of participants on 8mg doses discontinuing at least one antihypertensive medication by study completion

Exposure to the study drugs was additionally assessed continuously during follow-up (~per-protocol trial analysis), with censoring at the time of discontinuation or shift to the comparator drug

According to the MHRA/EMC SmPC, Wegovy follows a structured dose escalation schedule (0.25mg, 0.5mg, 1mg, 1.7mg, to maintenance 2.4mg weekly) specifically designed to improve tolerability

The understanding that obesity is a polygenic disease is well-established, with leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), and proopiomelanocortin (POMC) being prominent contributors