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see also review by Brierley & de Lartigue, 2021), or even elsewhere close to the circulation, which in turn release glutamate and peptide cotransmitters within the lower brainstem to convey postprandial satiation signals to the CNS (Figure 1)

On a reduced appetite, prioritise fiber-dense choices: legumes, whole grains, vegetables, fruit, nuts, and seeds, so that the smaller volume of food you do eat carries more fiber per bite

Acknowledging diversity in clinical manifestations, frequency of undiagnosed cases and limitations of therapeutic approaches in DN, efforts were recently put into the development of expert consensus recommendations for screening, diagnosis, and management of DN [10]

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