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The warning includes urging patients to contact their doctors if they experience severe or persistent gastrointestinal symptoms. Though the updated label doesnt specifically connect the warning to blockages or ileus, both conditions are associated with gastrointestinal symptoms

Zhao et al., 2006) and to improve LV function in dogs with dilated cardiomyopathy (Nikolaidis et al., 2005a), in which GLP-1 also attenuated reperfusion-related mechanical ventricular dysfunction not associated with irreversible myocardial damage (myocardial stunning) (Nikolaidis et al., 2005b)

In January of this year, the FDA noted that it had "received adverse event reports after patients used compounded semaglutide" and that "patients should not use a compounded drug if an approved drug is available to treat a patient." In July, the agency followed up with a notice that it had "received reports of adverse events, some requiring hospitalization, that may be related to overdoses due to dosing errors associated with compounded semaglutide injectable products." And in August, Eli Lilly, the maker of Zepbound and Mounjaro, sent a series of cease-and-desist letters to providers urging them to stop prescribing compounded versions of those drugs

Many are concerned about how GLP-1 therapy could affect testosterone, fertility, muscle preservation, and sexual health

Safety info: GLP-1 medications may have serious side effects, including possible thyroid tumors