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DURHAM, N.C

Ann Rheum Dis (2016) 75(3):593600

The STEP and SURMOUNT trials consistently showed 26 to 40 percent of total weight lost was lean mass

Several issues were reported regarding bias in the assessed articles

Finally, basal insulin could be added to the existing metformin regimen to reduce this patients hyperglycemia [85], but the initiation, titration, and optimization of add-on insulin therapies is beyond the scope of this review