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Phenanthridine sulfonamide derivatives as potential DPP-IV inhibitors: design, synthesis and biological evaluation

Tirzepatide has been shown to positively affect blood pressure, possibly due to improved endothelial function or decreased inflammation

doi: 10.3390/ijms23168942 157 ParkerJOBrienCHawrelakJGershFL

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Endogenous GLP-1 has a half-life of 2 minutes, as dipeptidyl peptidase enzymes rapidly inactivate incretin hormones