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7 Why Even Small Weight Loss Matters People who are overweight (BMI in the 25 to 30 range) drop less weight on GLP-1s than those with clinical obesity, losing just 5 to 10 percent of their body weight on average versus 15 to 20 percent for the obese cohort

Many people notice periods of fatigue as their body adjusts to weight loss, changes in appetite, and new routines

These are signs that the glucagon component is driving energy expenditure at a level that meaningfully contributes to the overall weight loss beyond what GLP-1 and GIP provide alone

The medicine may also be good for people with fatty liver disease

these are often temporary and may improve with time Seek immediate medical attention for signs of pancreatitis such as severe abdominal pain that may radiate to the back Inform your healthcare provider of all medications you take, as some drugs may interact with semaglutide