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The high demand for these drugs has resulted in shortages, so many patients and providers have turned to compounded tirzepatide, created at specialty pharmacies

However, its important to remember that weight loss is a gradual process and can be influenced by various factors, including diet, exercise, metabolism, and individual response to the medication

As of April 1, 2026, neither drug is on the shortage list or the 503B bulks list

had a serum calcitonin level (at visit 1) of 20 ng l 1 , if eGFR 60 ml min 1 1.73 m 2 35 ng l 1 , if eGFR 2 weeks or 14 days) systemic glucocorticoid therapy (excluding topical, intraocular, intranasal, intra-articular or inhaled preparations) or had evidence of a substantial, active autoimmune abnormality (for example, lupus or rheumatoid arthritis) that had required (within the past 3 months) or was likely to require, in the opinion of the investigator, concurrent treatment with systemic glucocorticoids (excluding topical, intraocular, intranasal, intra-articular or inhaled preparations) during the course of the study 33

Ongoing research will continue to clarify how they compare