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When I speak with patients, they tell me they want certainty, safety, and results that last beyond a few weeks

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They are also densely expressed in the VTA and nucleus accumbens the exact brain regions that drive addictive behavior

Email: # These authors contributed equally to this work (This article belongs to the Special Issue: Therapeutic Challenges in Targeting Cell Death) Oncology Research 2026 , 34 (1), 12 Received 05 September 2025

GLP-1 is primarily synthesized and secreted by specialized enteroendocrine cells called L-cells, which are located throughout the intestinal tract but are most concentrated in the distal small intestine (ileum) and colon