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The patients start with a health check-up which gathers past medical records, present medications, and weight issues

Medication alone rarely solves a chronic disease

Then, the 5-HT is successively converted into N-acetyl-5-hydroxytryptamine (NAS) and melatonin by arylalkylamine N-acetyltransferase (AANAT, EC: 2.3.1.87) and acetylserotonin O-methyltransferase (ASMT, EC: 2.1.1.4) (Figure 1)

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This paper is the first to report the cloning of LEPRs