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Unlike semaglutide and tirzepatide, retatrutide adds glucagon agonism to GLP-1 and GIP, boosting lipolysis and thermogenesis

Conclusion For patients experiencing weight regain after bariatric surgery, two-thirds of the weight regain can be safely lost with GLP1-RA, providing clinicians with a therapeutic option for this clinical challenge, and highlights the need for a large-scale randomized clinical trial

Combining prednisone with GLP-1 medications like semaglutide requires careful medical oversight due to their opposing metabolic effects