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Studies of exposure, metabolism, and interactions must treat orforglipron as a CYP3A-metabolized small molecule considering hepatic clearance, potential drugdrug interactions, and oral-absorption variables rather than applying the peptidase-degradation and renal-handling framework appropriate to peptides

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Practical scenarios: when alternating might make sense Despite the limitations, there are specific situations where alternating between semaglutide and tirzepatide could be a reasonable approach