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To compare the serum biomarker levels among different PD therapy intervention groups, we conducted an analysis of covariance (ANCOVA) for each biomarker, with group as a fixed factor and age, disease duration, and cognitive status, as defined by the MMP score, as covariates

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However, their findings have been critically questioned due to methodological limitations, including potential residual confounding, lack of dose and duration adjustment, absence of glycemic control data, and the biological implausibility of observing AD risk reduction within weeks of treatment initiation 83,84

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