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Those who responded well to moderate doses (4-8mg) did not necessarily need to escalate to the maximum 12mg

The effects on lipids are likely to reflect slowed gastric emptying and reduced delivery for absorption, as well as impact on hepatic and fat cell metabolism

[43,44] However, the immediate-release formulations frequent dosing may be less convenient, affecting patient compliance

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Surveillance without prohibition gives the field time for data to accumulate while avoiding enforcement problems against athletes who may have legitimate medical reasons to use these drugs, he said, noting that making a distinction between medical use and performance-driven use is going to be essential