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Retatrutide is not simply three peptides mixed together. Instead, it is a single engineered peptide molecule designed to activate three receptors through one carefully optimized molecular structure

In 2014, the FDA approved the first of these drugs specifically for weight loss for people with a BMI of 30 and above or a BMI of at least 27 with one weight-related comorbid disease, which affects more than half the U.S

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Contrave combines bupropion and naltrexone in a daily pill, while Wegovy contains semaglutide in a weekly injection