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While sulphonylureas potently promote insulin secretion in type-2 diabetic patients via inhibition of K ATP channel activity [[267], [268], [269], [270]], there is no clear evidence that sulphonylureas affect GLP-1 secretion in humans (as reviewed in [266])

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Someone starting at 300 pounds losing the same 30 pounds represents 10% reduction and often occurs in 46 months on semaglutide or 35 months on tirzepatide

There were no apparent differences in any of the other pharmacokinetic parameters between the 2 treatment periods

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