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In the LArginine rats , a significant increase in pAkt expression was detected in both the pancreatic acinar cells and islets after 4 and 8 days of treatment compared to the Control group
Post hoc mediation analysis across SURPASS-1 through SURPASS-5 found that decreases in systolic blood pressure (ranging from 1.3 mmHg to 11.5 mmHg across the tirzepatide doses) were primarily mediated through weight loss [91]
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