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Endogenous GLP-1 has a plasma half-life of under two minutes

At multivariate Cox regression analysis, diabetes duration (HR 1.08, 95% CI 1.021.14, P = 0.008) was the independent risk factor, and GLP-1 RAs therapy (HR 0.42, 95% CI: 0.200.88, P = 0.022) was the independent protective factor for the occurrence of MACEs in this population

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You should not use it if you have ever had medullary thyroid carcinoma or a family history of this, if you have a family history of MEN2 syndrome, or have ever had pancreatitis