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For semaglutide (Wegovy), treatment should be discontinued at least two months before a planned pregnancy, while liraglutide (Saxenda) should be stopped before pregnancy (with no specific lead time stated in the SmPC)

one Published Research The SURMOUNT and SURPASS trial programs provide extensive published documentation: SURMOUNT-1 through SURMOUNT-4: Obesity indication trials SURPASS-1 through SURPASS-5: Diabetes indication trials Extensive real-world evidence from post-marketing surveillance Published literature across multiple populations and demographics Retatrutide: GLP-1 + GIP + Glucagon Retatrutide represents the most comprehensive receptor coverage, activating all three pathways that Mazdutide and Tirzepatide divide between them

The identified proteases responsible for its rapid decay are DPP-4 (dipeptidyl peptidase-4) 34 , which cleaves selectively between residues 2 and 3, and NEP 24.11 35 , which cleaves at multiple sites