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Some people report that transdermal delivery produces smoother drug levels with potentially less GI disturbance, but large-scale comparative data is limited
A meta-analysis found co-administration of probiotics with antibiotics reduced the risk of antibiotic-associated diarrhea by 37 % [15]

[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Neeland I.J., Linge J., Birkenfeld A.L

Oral Contraceptives : Tirzepatide can reduce their effectiveness by up to 55%, increasing pregnancy risks

Less frequent dosing means less frequent GI stimulation, which can help with constipation , nausea, and bloating that some patients experience throughout treatment
