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However, it is not yet widely used in the field of pharmacovigilance
J Neuroimmunol
Furthermore, cardiovascular and renal disease are the predominant cause of premature mortality in type 1 diabetes [13]
Ex-4 modulates apoptotic pathways in the hippocampus through the regulation of the expression levels of Bcl2, Bax, and caspase-3 [71], and it improves mitochondrial function and integrity in AD mice through the PI3K/Akt signaling pathway [72]
A pilot study demonstrated that pioglitazone led to cognitive and metabolic improvements in patients with diabetes with AD or MCI [34]
