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Abstract Glucagon-like peptide-1 (GLP-1) enhances meal-related insulin secretion, which lowers blood glucose excursions

Soricelli E, Casella G, Baglio G, et al

Discussion Protection of L-cell function represents a strategy in the promotion of GLP-1 secretion in favor of treatment of type 2 diabetes 2,21,22

These drugs also activate GLP-1 receptors in the hypothalamus, which increases the release of anorexigenic peptides like pro-opiomelanocortin while reducing the release of orexigenic peptides like neuropeptide Y and agouti-related peptide

"The key takeaway is that most of these companies are doing this for a small number of products and in a limited setting," says Dr