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While originally approved for type 2 diabetes and cardiovascular disease, these drugs have demonstrated significant efficacy for weight loss, fueling public demand and legislative proposals to expand coverage

Mechanism of action of GLP-1 receptor agonists: Direct receptor binding These medications bind specifically to GLP-1 receptors on pancreatic beta cells, stimulating insulin secretion in a glucose-dependent manner (meaning they work when blood glucose is elevated)

11 It is often administered as a weekly subcutaneous injection, but it can also be taken daily orally, as previously noted in Table 1

In this context, berberine has emerged as a powerful ally