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Weight-independent changes in blood glucose homeostasis after gastric bypass or vertical sleeve gastrectomy in rats

10.2337/diabetes.54.1.146 11 BragazziN

Tryptophan 33 in GLP-1R is required for PF-06882961 signaling Prior to the selection of animal models for in vivo pharmacology studies, we characterized the potential for species differences in GLP-1R activation with our small-molecule agonists

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Together, these studies add to growing evidence that GLP-1 drugs may influence pathways involved in biological aging
