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The global obesity epidemic has resulted in significant morbidity and mortality

Novo Nordisk is putting down up to US$362m to tap into Ascendis TransCon technology for treatments in metabolic and cardiovascular diseases

Thus, the SELECT trial exceeded expectations (many commentators predicted the topline reduction to be likely sub-20%), but also underlined the need for further outcomes trials to clarify other potential benefits, as well as, for competitors, meeting or exceeding the performance of Wegovy

Although early observational studies report improvements in HS severity, larger, randomized controlled trials are needed to establish their role in HS disease management.

For expensive drugs such as glucagon-like peptide 1 receptor agonists (GLP-1s), payer coverage is crucial for patient affordability