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The approval was backed by the Phase II open-label AGAVE-201 trial, where treatment with a 0.3-mg/kg dose of Niktimvo elicited an overall response rate of 75%, with a median time to response of 1.5 months

Prior studies have reported the expression of GLP-1R in mouse endothelial cells and human trophoblast cells (20, 40, 41)

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