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Description
These approaches support the development of comprehensive mechanistic models in controlled laboratory systems

GLP-1 receptor agonists mimic this hormone, triggering several beneficial effects: With such powerful benefits, its no surprise that GLP-1 drugs are gaining traction not just among diabetics but also among individuals looking for weight loss solutions

Psychopharmacology 243 , 11851197 (2026)

In addition, discovery of the dipeptidyl peptidase-4 (DPP4)-resistant GLP-1R agonist exendin-4 (EX-4) enabled much of our current understanding of GLP-1R activation on glucose homeostasis via studies in animal models [5], [6]

Hartman ML, Loomba R, Lawitz EJ, et al
