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While other trials did not include proteomic analysis, the findings of metabolic improvements and weight loss indirectly suggest alterations in key metabolic proteins 34,52 (Table 3)

This commentary provides practical advice for healthcare providers facing this challenge

Resources: Pillar 2: Weight management (fat loss where appropriate) Where excess body fat (especially visceral and ectopic fat) is present, fat loss can materially improve insulin sensitivity

Berberine also demonstrated the ability to normalize lipid profiles, with TC, and LDL-C all decreasing, and HDL-C increasing in human trials

But by reducing the metabolic inflammatory noise, the signal becomes more manageable