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Researchers use receptor-knockout models and selective blockers to try to untangle it, but in humans the contributions remain estimates

Because it targets fat absorption and not appetite, there are no effects on hunger or fullness

You cant have bariatric surgery because of a medical or psychological condition that would make surgery harmful

Future research directions highlight the pressing need to explore how increased pharmaceutical spending impacts individuals, payors, and the healthcare system, as well as the effectiveness of newer drugs

GLP-1 tirzepatide may be considered for adults who have struggled with weight despite lifestyle changes, have weight-related or metabolic health concerns, prefer non-surgical medical weight loss options, and meet eligibility criteria after medical evaluation