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Therefore, our initial investigation set out to provide a comprehensive analysis of the potency of tirzepatide at the mGIPR to identify potential limitations of using mouse models to study the actions of tirzepatide

74 In a comparative study in obese male mice of vertical sleeve gastrectomy (VSG), semaglutide treatment, and controls, both interventions improved glycemic control and reduced body weight, but VSG significantly decreased energy expenditure and induced notable bone loss, whereas semaglutide preserved BMD over six weeks

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Soliqua also contains lixisenatide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist