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Accessed 23 August 2021 26.Tridgell DM, Spiekerman C, Wang RS, Greenbaum CJ

Highly palatable, high-calorie foods typically trigger a significant dopamine release, creating a pleasurable sensation that encourages repeat consumption

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Importantly, leptin receptor knockdown did not yield changes in food-motivated behavior, while potent and lasting upregulation of food motivation was found here after GLP-1R knockdown, at least in males

When you no longer feel the biological drive to eat, it is easy to skip meals entirely
