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Antibodies to exenatide did not cross-react with human GLP-1 or glucagon or alter the efficacy or safety of exenatide [abstract 858]

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In the SURMOUNT-1 trial, tirzepatide produced dose-dependent weight reductions, with average losses approaching or exceeding ~20% at higher doses in adults with obesity who did not have diabetes, numbers that markedly exceed historical pharmacotherapy benchmarks

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1mL), which can reduce irritation

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We found that GLP-2R has the most protruded ECL1 with a height of 22.6 and this ECL1 closely attaches to GLP-2 with the largest interface area of 791 2

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In addition to its expression in pancreatic -cells, GIPR has been reported to be expressed in many other organs, including the gut, white and brown adipose tissue, heart, pituitary, and inner layers of the adrenal cortex, bone, and several regions in the brain, contributing to various extrapancreatic effects of GIP [17-21]

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