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Although the majority of absorbed Trp is directed into the kynurenine pathway via indoleamine 2,3-dioxygenase (IDO) in extrahepatic organs, or tryptophan 2,3-dioxygenase in the liver, culminating in NAD + synthesis [19], around 3% of absorbed Trp is converted into serotonin [20]

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Retatrutide (LY-3437943) is a unipeptide that simultaneously activates GLP-1, GIP, and glucagon receptors

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