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The most common side effects are gastrointestinal (think: constipation, diarrhea, or an upset stomach)

long-term vascular-risk reduction months earlier is a different clinical target

Food Motivation Willingness to work to obtain food is not surprisingly enhanced by a negative energy balance, but even under conditions energy repletion or sufficiency, food-motivated behaviors are influenced by gut peptides such as ghrelin and GLP-1

Originally intended for the treatment of type 2 diabetes, clinical trials found that they are also able to treat obesity by significantly decreasing a patients appetite