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Some studies suggest chromium supplementation may help with insulin sensitivity, though direct connections to GLP-1 enhancement remain unclear

The association between HFpEF and CMD was first proposed in 2013 [11]

Innovation was never a problem

Key points: Leverage platform data from similar biologics Eliminate redundant toxicology studies Combine endpoints within the same study Use in vitro and computational models earlier Align with the 3Rs principle (Replacement, Reduction, Refinement) Important step toward more ethical and efficient ocular drug development

Moreover, the increased morbidity and mortality in patients with NASH is known to be closely related to the severity of liver fibrosis