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This testing is done in animal models, typically rodents

The GLP-1-specific adaptations recognise that protein intake is particularly important during GLP-1 treatment to preserve muscle mass

In fact, such a design incorporates substantial uncertainty if background therapy, population risk, or adherence differs significantly from historical trials, especially in view of the rapidly changing scenario of T2D management with a treat-to-benefit approach

Future directions Considering the GLP-1 RAs currently available for treating T2DM and obesity, along with the numerous new GLP-1 RAs, dual, and triple agonists in development, we anticipate a shift in clinical practice towards more personalized and tailored use of these agents to meet individual patient needs

Little to no weight change initially: Significant weight loss typically becomes more evident from weeks four to eight onwards, as the dose is increased and the body responds to sustained appetite reduction