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Risk of Gastrointestinal Adverse Events with GLP-1 Receptor Agonists for Weight Loss

11.4 Lean Mass Preservation Is Foundational Preserving lean mass: Protects metabolic rate Supports long-term weight maintenance Preserves functional capacity Maintains micronutrient intake indirectly Protein adequacy often has greater downstream impact than broad micronutrient supplementation

And it is not that the math is wrong or that calories and calories out is wrong exactly

The researchers compared the one-year risk of HF hospitalization or death in new users of each GLP-1 drug to the risk of those outcomes in a placebo group of patients taking sitagliptin, a diabetes drug known to have no impact on HFpEF