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Most of the insulin granules (9599%) belong to the reserve pool while a smaller fraction (only 15%) belong to the readily releasable pool that is thought to reside closer to the plasma membrane than the reserve pool [54]

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Post-treatment, the expression of the serotonin reuptake transporter (SERT) significantly increased, while tryptophan hydroxylase-1 (TPH-1) expression significantly decreased in colonic tissue, suggesting exendin-4 mitigates visceral hypersensitivity by upregulating SERT and downregulating TPH-1

The interaction between CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) on Tregs and its ligand CD80/86 on APCs provides a negative signal for T cell activation (2)